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KMID : 0377519850100030291
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Chung-Ang Journal of Medicine
1985 Volume.10 No. 3 p.291 ~ p.306
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Effect of Prednisolone on the Intestinal Lesion Caused by Metagonimus yokogawai
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Kim, Eun Ryung/김은령
Kim Suk-Il/Kang, Shin-Yong/Cho, Seung-Yull/김석일/강신영/조승열
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Abstract
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This study was undertaken in order to observe the effect of anti-inflammatory activity of prednisolone on the worm numbers and the pathogenesis of villous atrophy in experimental model of metagonimiasis. A total of 17 adult cats was divided into 3 normal control, 7 infected control and 7 infected/prednisolone-treated groups. Infected/prednisolone-treated cats were, daily injected intramuscularly with 1 mg /kg/day of methyl-prednisolone from 5 days before the experimental infection to the day of killing. Experimental cats were orally challenged´with 10, 000 metacercariae of Metagonimus yokogawai, and were killed on 3, 7, 10,15 days and 1, 2, and 3 rnonths after the experimental infection. Three cm long histologic samples were taken at 6 small intestinal segments of equal length. The thickness.of mucosa, length of villi and crypt height were measured. From the f ormalin-f ixed tissue of the intestinal segments, the worms were recovered. The results were summarized as follows:
1. The recovered worm numbers were higher in infected/prednisolone-treated group than in the infected control in early stage of infection up to 10 days. The:reaf ter, the worm number was not different between the experimental groups.
2. The distribution of M. yokogawai was not different between two experimental groups. Majority of worms were recovered from the first to fourth segments of the small intestine. The distribution pattern was different
by individual cat, either aggregated in a segment or diffusely distributed. These findings suggested that the worms migrated in small intestine to escape the bad habitat with shortened and fused villi which were made by themselves.
3. The villous length/crypt height ratio was not significantly different between the infected control and the infected/prednisolone-treated groups.
4. Cats in two experimental groups showed that the V/C ratio, average percentage of mucosal thickness to normal, average percentage of villous length to normal were all correlated inversely with the number of worms´ recovered.
From the above results, it was inferred that the anti-inflammatory activity of prednisolone did affect neither the number of infected tYl. yokogawai nor the shortening of the villous length.
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